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KMID : 0366220080430030166
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Korean Journal of Hematology
2008 Volume.43 No. 3 p.166 ~ p.169
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All-trans Retinoic Acid-induced Nephrotic-range Proteinuria in a Patient with Acute Promyelocytic Leukemia
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Lim Seong-Uk
Lee Se-Ryeon
Lee Je-Jung
Kim Hyeoung-Joon
Kim Yeo-Kyeoung
Yang Deok-Hwan
Seo Seong-Rye
Ahn Jae-Sook
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Abstract
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All-trans retinoic acid (ATRA) is a potent differentiating agent for the treatment of acute promyelocytic leukemia (APL). Although ATRA is generally well-tolerated, some patients develop side effects, the most severe of which is ATRA syndrome. We report on a patient with APL who developed isolated nephrotic- range proteinuria during ATRA therapy for remission-induction. ATRA was discontinued and the proteinuria decreased significantly 5 days after dexamethasone treatment. The occurrence of isolated proteinuria during ATRA treatment is a rare adverse event.
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KEYWORD
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Proteinuria, Acute promyelocytic leukemia, All-trans retinoic acid
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